Dietary effects on glycogen and lipoprotein lipase activity in skeletal muscle in man

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Abstract
The influence of short-term adaptation to a fat and protein enriched diet (F+P) and a carbohydrate enriched diet (CHO) on skeletal muscle lipoprotein lipase (LPL) activity and muscle glycogen levels was evaluated in 7 males. Muscle biopsies were taken from the m. vastus lateralis after an uncontrolled, mixed diet (M), after a 3 day F+P diet preceded by intense exercise, and after a 3 day CHO diet. After the F+P diet glycogen concentration was 55% that of the M diet while LPL activity increased by 21% (n. s.). After the CHO diet glycogen levels increased by 82% and LPL activity decreased by 55% compared to the M diet (ppp<0.01). The results suggest that the uptake of fat from the circulation may be actively regulated by the muscle as a function of intramuscular substrate availability and that this regulation may be related to muscle fibre type composition.