Activation of the c-mos oncogene in a mouse plasmacytoma by insertion of an endogenous intracisternal A-particle genome.

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Abstract
The activation of the cellular oncogene c-mos in mouse plasmacytoma XRPC24 was found to result from the insertion of a 4.7-kilobase-pair cellular DNA element, whith the c-mos coding region. The element terminates on both sides with a direct repeat of .apprx. 335 nucleotides. The repeat as well as internal sequences of the element show strong homology to endogenous intracisternal A-particle (IAP) genes. The IAP genome integrated within c-mos in a head-to-head (5'' to 5'') configuration. This juxtapositioned the IAP 5'' long terminal repeat next to the bulk of the oncogene''s coding region and shifted c-mos 5'' coding and flanking sequences to a position further upstream. The significance of several aspects of this activation and transposition event is discussed.