Listeria monocytogenes-reactive T lymphocyte clones with cytolytic activity against infected target cells.
Open Access
- 1 July 1986
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 164 (1) , 363-368
- https://doi.org/10.1084/jem.164.1.363
Abstract
Lyt-2+ T cell clones were established from Listeria monocytogenes-infected mice. The clones secreted IFN-gamma after stimulation with spleen cells from L. monocytogenes-infected mice plus IL-2. Spleen cells from normal mice were not stimulatory. Furthermore, cloned T cells lysed L. monocytogenes-infected macrophages. Cytolysis was antigen-specific and H-2K-restricted. These findings suggest a role for specific cytotoxic T cells in the immune response to intracellular bacteria.This publication has 13 references indexed in Scilit:
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