Inhibition of the Release of the Ovulating Hormone in Immature Rats with Hypothalamic Lesions11

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Abstract
PMS-induced ovulation in immature rats involves a neuroendocrine pathway. Bilateral electrolytic lesions located in the medial preoptic area, basal-medial preoptic area, or ventral medial anterior hypothalamic area prevented the ovulatory response following a single injection of PMS (pregnant mare''s serum). Lesions of the medial preoptic area failed to interfere with ovulation following treatment with PMS and HCG (human chorionic gonadotropin). Electrode placement (sham) into the medial preoptic area failed to alter PMS-induced ovulation. PMS-induced ovulation occurred in the presence of bilateral lesions located in other areas of the hypothalamus than those listed above. From these experiments it is concluded that the mechanism of PSM-induced ovulation involves the medial preoptic and basal anterior hypothalamic regions.