Observations on Antigenic Variants of Echovirus Type 11.

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Abstract
Summary Strains of echovirus type 11 isolated in this laboratory since 1962 appear to have a broader antigenic spectrum than the prototype Gregory strain. The isolates were neutralized to low titer or not at all by immune serum to the Gregory strain, but immune serum to a representative isolate (Silva) neutralized both the prototype and homologous strains, as well as the other isolates. Results of cross hemagglutination inhibition and complement fixation tests, as well as im-munodiffusion tests, confirmed the relationship of these isolates to echovirus type 11. Sera of patients from whom the antigenic variants were recovered showed significant neutralizing antibody responses to both the prototype echovirus type 11 strain and the Silva “prime” strain.