Mixing Action and Evaluation of Tablet Lubricants in Direct Compression

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Abstract
The effect of a series of modern lubricants during mixing on both lubricating action and binding properties of a direct compressible tablet formulation has bean investigated and compared with the effect of magnesium stearate. Lubricants which gave the best lubricating action (magnesium stearate, hydrogenated vegetable oils and glycerides) caused the largest reduction in tablet strength with an increase in. mixing time. When used in concentrations of It. the hydrogenated vegetable oils and glycerides tested gave about the same reduction of the ejection force as 0.5% magnesiun stearate, but their effect on tablet hardness during mixing was much smaller. This result was conflrmed for three direct compressible tablet formulations, composed with different excipients, where magnesium stearate could be replaced advantageously by Boeson VP or sterotex.

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