In Vitro Action of Mustards on the Infective and Toxic Components of Influenza A (PR8) Virus

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Abstract
Summary: The 5 × 10−3 M solutions of mustards (except methyl mustard) caused inactivation of influenzal toxin and complete or nearly complete destruction of viral infectivity. The 5 × 10−4 M solutions of chemicals caused either complete or partial suppression of viral toxicity and marked reduction of viral infectivity. Very little effect upon these two viral properties was apparent with 5 × 10−5 M mustards. The intensity of inactivation of viral toxicity by cyclo and sulfur mustard was a function of the concentration of mustard. The destruction of viral infectivity by mustard appeared to be influenced by concentration of virus and/or of extraneous substances associated with virus. Pretreatment of eggs with near lethal doses of cyclo mustard failed to influence the reproduction of active virus. The rate of destruction of viral infectivity by cyclo mustard and of viral infectivity and toxicity by sulfur mustard was a rapid one and appeared to be completed within 30 minutes at room temperature (25 C).

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