The role of polymorphonuclear leucocytes and T lymphocytes in experimental murine amyloidosis

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Abstract
Washed cells from ascitic fluid, which contained predominantly polymorphonuclear leukocytes from casein treated donor mice, induced accelerated amyloid formation in untreated syngeneic recipient animals. A similar transfer model, with lymph node cell suspension, was ineffective. Amyloidogenesis was completely blocked by colchicine treatment of the donors; treatment of the recipients had no effect. A casein induced amyloidogenic stimulus was transferred from nude C3H mice to their normal littermates. When the order was reversed, no amyloidosis occurred in the nude recipients. The possible involvement of 2 cells in the biphasic process of casein induced murine amyloid formation is indicated, the polymorphonuclear leukocyte in the 1st phase and the T [thymus-derived] lymphocyte in the second.

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