Further Aspects of T Cell Function in Systemic Lupus Erythematosus
- 1 January 1982
- journal article
- research article
- Published by Taylor & Francis in Immunological Communications
- Vol. 11 (2) , 113-120
- https://doi.org/10.3109/08820138209057747
Abstract
Generation of effector cells, the expression of cell mediated lympholysis (CML) and the reactivity of mononuclear cells in solid cultures, were explored in patients with Systemic Lupus Erythematosus (SLE). While proliferative responses to alloantigens were comparable to the controls, a significant decrease in CML capacity was found in SLE T lymphocytes; further, T cells stimulated with a T cell mìtogen in solid cultures showed a disminished proliferative response to soluble factors. Functional cell interaction defects rather than intrinsic T cell abnormalities may be operating in SLE.This publication has 16 references indexed in Scilit:
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