Studies of Tissue Response to Injections of Enzymes

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Abstract
Hexosamine-containing polysaccharides have been demonstrated in plasma and various tissues including skin, cartilage and heart. Plasma hexosamine elevations have been observed in rheumatic fever, sterile infarcts and tuberculosis. It is possible that plasma polysaccharide changes reflect alterations of tissue polysaccharides. Thirty-six hours following a single subcutaneous injection of trypsin, a significant elevation of tissue hexosamine occurred at the injection sites. This appeared long before any visible or palpable change. The tissue hexosamine paralleled the developmental course of the "nodules." These findings appear specifically related to trypsin, since they failed to occur with other enzymes or test substances.