Histidine‐rich glycoprotein is evolutionarily related to the cystatin superfamily
- 25 May 1987
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 216 (1) , 17-21
- https://doi.org/10.1016/0014-5793(87)80748-2
Abstract
A new member of the cystatin superfamily is introduced. Human plasma histidine-rich glycoprotein (HRG) was found to contain 2 cystatin-like sequences in tandem in the N-terminal region. Domain 1 (residues 1–112) was most homologous to domain 1 of the heavy chain of human kininogen and domain 2 (residues 113–225) was most homologous to human cystatin S as well as other cystatins and domain 3 of the heavy chain of kininogen, suggesting that the cystatin domains of HRG may represent a hitherto unknown binary form (or intermediate molecule) composed of 2 cystatin domains, and evolutionarily intermediate between the cystatin and the kininogen families.Keywords
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