Renal Tubular Excretory Mass and the Reabsorption of Sodium, Chloride and Potassium in Female Dogs Receiving Testosterone Propionate or Estradiol Benzoate
- 31 March 1951
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 165 (1) , 93-101
- https://doi.org/10.1152/ajplegacy.1951.165.1.93
Abstract
Testosterone propionate in 10 to 12 daily intramusc. doses of 3, 6, and 10 mg./kg. had no significant effect on tubular excretory mass for p-aminohippuric acid [TmPAH] and a questionable lack of effect on the renal tubular reabsorption of Na, Cl, and K in female dogs. Estradiol benzoate in daily, intramusc. doses of 0.0133 to 0.33 mg.Ag. for 6-17 days in some instances caused a reduction in glomerular filtration rate. Reabsorbed K and TmPAH were decreased and later returned to normal. In treated animals no significant changes occurred in the histology of the kidney or in the kidney wt./body wt. ratio. In all animals, the reabsorption of Na and Cl bore a directly proportional relationship to the rate of glomerular filtration.Keywords
This publication has 1 reference indexed in Scilit:
- The Effects of Certain Hormones on the Renal Function of Man 1Journal of Urology, 1945