Detection of HLA‐A*24 null alleles by DNA typing methods
- 1 September 1998
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 52 (3) , 208-212
- https://doi.org/10.1111/j.1399-0039.1998.tb03034.x
Abstract
A number of cases have been identified (seven unrelated individuals from the Northern Ireland bone marrow donor registry and two family groups) where an HLA‐A*24 allele fails to express the normal HLA‐A24 antigen. Family information has revealed common haplotypes with respect to each non‐expressed allele indicating that the occurrence of these mutations has been a recent event. Two methods for the clinical typing of these alleles have been evaluated ‐ PCR‐SSOP and PCR‐SSCP analysis.Keywords
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