Carbonyls in Oxidizing Fat. VI. The Girard T Reagent in the Isolation and Determination of Micro Amounts of N‐Aliphatic Aldehydes and 2‐Alkanones

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Abstract
SUMMARY: Complete reaction of the Girard T reagent with n‐alkanals, alk‐2‐enals, alk‐2,4‐dienals, and 2‐alkanones of carbon chain length up to C‐13 was obtained in anhydrous tertiary butyl alcohol. However, in practical applications in the presence of fat these reactions were greatly retarded and inhibited. Modification by the use of water in the reaction gave quantitative recovery of aldehyde homologous series from the fat. Quantitative or even uniform recovery of 2‐alkanones could not be obtained. Optimum reaction with the Girard T reagent was at room temperature, and refluxing tended to decrease yields. Girard T hydrazones were. converted quantitatively to 2,4‐dinitrophenylhydrizones. The method is useful for the determination of aldehydes generated in autoxidized fats.