INFLUENCE OF NEUROLEPTICS ON THE BEHAVIORAL-EFFECT OF 5-HYDROXYTRYPTOPHAN

  • 1 January 1978
    • journal article
    • research article
    • Vol. 30  (4) , 431-440
Abstract
The antagonism of neuroleptics of various groups (chlorpromazine, chlorprothixene, clopenthixol, clozapine, flupenthixol, fluphenazine, haloperidol, levomepromazine, mepazine, perazine, perphenazine, pimozide, prochlorperazine, promazine, spiperone, thiopromazine, thioridazine, trifluoperazine, trifluperidol, triflupromazine) towards L-5-hydroxytryptophan (5-HTP) was assessed on the basis of inhibition of characteristic head-twitches. ED50 was assayed in mice and rats. The results indicate that all investigated neuroleptics inhibit the action of 5-HTP and their ED50 values are, as a rule, lower than the values of ED50 for catalepsy. That action is for the majority of neuroleptics more pronounced in mice than in rats. Possible serotonergic, dopaminergic and also noradrenergic mechanisms of neuroleptic action in the 5-HTP test are discussed.