Kinetics of Diphtheria Toxin Formation
- 1 July 1962
- journal article
- research article
- Published by Microbiology Society in Journal of General Microbiology
- Vol. 28 (3) , 531-539
- https://doi.org/10.1099/00221287-28-3-531
Abstract
Studies on the kinetics of diphtheria toxin formation in iron-free culture media by variants of the PW no. 8 strain of Coryne-bacterium diphtheriae labelled with 14c -phenylalanine or 35S-methionine showed that the toxin protein was synthesized de novo from amino acids by growing organisms. Release of toxin into the extracellular medium occurred without lysis of more than a minor proportion of the bacterial population.Keywords
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