HLA‐E polymorphism in patients with recurrent spontaneous abortion

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Abstract
The aim of this study was to compare the frequencies of five HLA‐E alleles in 82 women with recurrent spontaneous abortions with that of 150 random Danish controls. PCR sequence‐specific oligonucleotide typing was carried out to detect polymorphism in exons 2 and 3 of the HLA‐E gene. In informative samples sequencing of these two exons was also undertaken to confirm the presence of the HLA‐E*01031 allele. HLA‐E*0101, HLA‐ E*01032 and HLA‐E*01031 were detected with frequencies of 56.7%, 33.6% and 9.6% in controls and 58,5%, 32.9% and 8.5% in patients with recurrent abortion, respectively. No HLA‐E*0102 and E*0104 alleles could be detected. Since the HLA‐E allele distribution was similar in women with recurrent spontaneous abortion and controls, it is suggested that maternal HLA‐E polymorphism per se does not play any role in the pathogenesis of this disorder of pregnancy.