Effect of D-(--)-ribose on the turnover of glucose in dogs

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Abstract
An intra-venous infusion of D-(-)-nbose to normal nonanesthetized dogs was found to decrease markedly the concentration of glucose [GLU] in the blood plasma. Confirming reports of others in humans, no increase, or only a small and transient one, in the concentration of plasma insulin was detected in mixed venous blood during the infusion. The rate of the endogenous GLU production, calculated by a tracer-infusion method, decreased during the 1st 45 min. of the ribose infusion, later (45-100 min.) it returned to its preinfusion level. The metabolic clearance of GLU increased, indicating enhanced GLU utilization. Effects of a ribose infusion on GLU turnover could be stimulated by an intraportal infusion of canine insulin at 1-3 mU/kg per min. Ribose effectively prevented or counteracted, at least transiently, the increase in the rate of endogenous GLU production evoked by the infusion of phlorizin. The importance of the release of insulin as a causative factor in ribose-induced hypoglycemia is confirmed, but other factors affecting rates of hepatic GLU production are also recognized.