6,7‐Dihydro‐4H‐indolones: Synthesis and biological properties
- 1 October 1991
- journal article
- research article
- Published by Wiley in Archiv der Pharmazie
- Vol. 324 (10) , 767-771
- https://doi.org/10.1002/ardp.2503241001
Abstract
Syntheses of 6,7-dihydro-4H-indolones 6 and 10 by a selective Birch reduction of the benzene ring of the indole system are described. The antiestrogen zindoxifene and the 2-phenylindole 2 as well as 6 and 10 were tested for their relative binding affinities at the androgen receptor as well as for antiandrogenic and estrogenic properties. Both compounds 6 and 10 showed potent indirect antiandrogenic activity which were similar to those of the 2-phenyl-indoles zindoxifene and 2.Keywords
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