PERSONALITY STRUCTURE IN RELATION TO TETRAETHYLTHIURAMDISULFIDE (ANTABUSE®) THERAPY OF ALCOHOLISM

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Abstract
It was only two years ago that the Danish physicians Hald, Jacobsen and Larsen1 announced their discovery of the sensitizing effect of tetraethylthiuramdisulfide (antabuse®2) to ethyl alcohol; and it was only shortly thereafter, in association with Martensen-Larsen,3 that they told of their initial clinical experience with this substance in the treatment of chronic alcoholism. During these two years this drug has received increasingly frequent use. In the near future we shall publish an article4 reviewing the literature to date. Four other papers5 on tetraethylthiuramdisulfide in the treatment of alcoholism were read at the American Psychiatric Association meeting in May 1950. For purposes of brevity, we shall say little about the pharmacology and toxicology of this drug. It will suffice to mention that tetraethylthiuramdisulfide in some way alters the normal metabolism of ethyl alcohol, resulting in the formation of acetaldehyde in the blood stream, which creates

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