Fever can cause pyuria in children

Abstract
We studied 157 children (73 girls), mean age 2.7 years (range 12 days to 15 years) in a paediatric day unit. Seventy febrile children (temperature >/=38°C) attended for clinical assessment, and 87 afebrile children (temperature </=37°C) attended for various investigations. The febrile and afebrile groups were similar in distribution of age and sex. No child had haematuria, proteinuria, or a urinary tract infection at the time of study, and none had renal tract disease. One of us (GMT) examined a urine sample within 30 minutes of collection by means of a Neubauer counting chamber and phase contrast microscopy at a magnification of 400. Leucocytes were counted in 0.9 μl of uncentrifuged midstream urine samples or bag collections of urine in which there were no bacteria present.4 Creatinine concentration and osmolality were measured in most specimens. When venesection was indicated clinically (32 febrile and 22 afebrile children) the blood neutrophil count was measured.