Carrier estimations in Duchenne muscular dystrophy families in Northern Ireland using RFLP analysis.
Open Access
- 1 February 1990
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 27 (2) , 101-104
- https://doi.org/10.1136/jmg.27.2.101
Abstract
Intragenic RFLP analysis was used to provide carrier risk estimations on 100 possible female carriers from 22 Duchenne muscular dystrophy families. This enabled 78% of possible carriers to be assigned high or low risks (greater than 90% or less than 10%) as opposed to 26% assigned low risk on pedigree data alone. When a single polymorphism is not informative the use of haplotype analysis for carrier estimations is illustrated for one family.This publication has 10 references indexed in Scilit:
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