Autophosphorylation at Thr 286 of the α Calcium-Calmodulin Kinase II in LTP and Learning
- 6 February 1998
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 279 (5352) , 870-873
- https://doi.org/10.1126/science.279.5352.870
Abstract
The calcium-calmodulin–dependent kinase II (CaMKII) is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)–dependent activity, CaMKII can undergo autophosphorylation, resulting in CaM-independent activity. A point mutation was introduced into the αCaMKII gene that blocked the autophosphorylation of threonine at position 286 (Thr 286 ) of this kinase without affecting its CaM-dependent activity. The mutant mice had no N -methyl- d -aspartate receptor–dependent LTP in the hippocampal CA1 area and showed no spatial learning in the Morris water maze. Thus, the autophosphorylation of αCaMKII at Thr 286 appears to be required for LTP and learning.Keywords
This publication has 38 references indexed in Scilit:
- Control of Memory Formation Through Regulated Expression of a CaMKII TransgeneScience, 1996
- Inactivation of NMDA Receptors by Direct Interaction of Calmodulin with the NR1 SubunitCell, 1996
- Ca2+/Calmodulin Kinase II Translocates in a Hippocampal Slice Model of IschemiaJournal of Neurochemistry, 1995
- The role of calcium–calmodulin kinase II in three forms of synaptic plasticityCurrent Biology, 1994
- Intrahippocampal or intraamygdala infusion of KN62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, causes retrograde amnesia in the ratBehavioral and Neural Biology, 1994
- Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.Proceedings of the National Academy of Sciences, 1993
- Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant MiceScience, 1992
- An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiationNature, 1989
- Expression of a multifunctional Ca2+/calmodulin-dependent protein kinase and mutational analysis of its autoregulationPublished by Elsevier ,1989
- Sequences of autophosphorylation sites in neuronal type II CaM kinase that control Ca2+-independent activityPublished by Elsevier ,1988