Absolute Lymphocyte Count and Serum Inorganic Phosphorus After Glucose Administration in Diabetic Patients

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Abstract
Of 17 diabetic patients studied 9 showed a change of the absolute lymphocyte count following admn. of glucose which change differed from that observed in the normal controls, while 8 had a decline of the absolute lymphocyte count similar to to that in the controls. All 9 patients with an abnormal lymphocyte response also had an abnormal response of serum inorganic P after admn. of glucose. It is suggested that these findings indicate pituitary-adrenal dysfunction as the patho-genetic factor of the diabetic syndrome in these patients. Six of the 8 patients with a normal change of the absolute lymphocyte count had also a normal decline of serum inorganic P after glucose admn. suggesting a non-endocrine diabetes which is presumed to be due to hepatic dysfunction. The other 2 patients with a normal absolute lymphocyte response associated with an abnormal serum inorganic P response after glucose admn. are believed to have a primary insulin-deficiency diabetes.

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