Radiation dose enhancement in tumors with iodine

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Abstract
The loading of tissue with I can result in the enhancement of the radiation dose absorbed from low-energy X-ray or .gamma.-ray sources. The potential of this phenomenon for radiation therapy was studied. The effect was demonstrated of I concentration and radiation quality on this dose enhancement in lymphocytes. The effect was calculated of such enhancement of depth dose distributions in the brain. The I content was estimated in 2 human brain tumors during computerized tomography (CT) scans. The dispersion was studied of the I contrast media after direct injection into rabbit tumors [VX2 carcinoma cells]. The combination of X-ray and contrast media injection is far more effective than either agent alone in causing the regression of mouse tumors [Ehrlich ascites tumor]. There may be a therapeutic advantage from loading tumors with I and treating them with low-energy photons.