A STUDY OF EIGHT HEATED PLASMA PROTEIN PREPARATIONS

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Abstract
Comparison by physical and chemical means of plasma preparations heated to diminish the hepatitis risk indicated that materials derived from partially fractionated human plasma were in general more resistant than whole plasma preparations to protein changes on being heated for 10 hours at 60[degree] C in the presence of stabilizers. Those showing least change and seeming most worthy of more intensive chemical, immunological and clinical testing were, respectively, a precipitate from supernatant IV-1 of Conn''s fractionation method 6, fractions IV+V of Conn''s method 6, and a preparation from the supernatant of plasma 45% saturated with ammonium sulfate. The presence of reducing sugars in the whole plasma preparations seemed to increase their susceptibility to heat denaturation.