Carcinogenicity in Mice of Mutagenic Compounds from a Tryptophan Pyrolyzate
- 17 July 1981
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 213 (4505) , 346-347
- https://doi.org/10.1126/science.7244619
Abstract
The compounds 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole and 3-amino-1-methyl-5H-pyrido[4,3-b]indole, which are potent mutagens in a tryptophan pyrolyzate, ar hepatic carcinogens when given orally to mice at concentrations of 200 parts per million in a pellet diet. Female mice showed higher susceptibilities to both compounds than male mice.Keywords
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