LUTEINIZING HORMONE‐RELEASING FACTOR AND MUSCARINIC AGONISTS ACT ON THE SAME VOLTAGE‐SENSITIVE K+ ‐CURRENT IN BULLFROG SYMPATHETIC NEURONES
Open Access
- 1 March 1980
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 68 (3) , 353-355
- https://doi.org/10.1111/j.1476-5381.1980.tb14547.x
Abstract
The effect of bath‐applied luteinizing hormone‐releasing factor (LHRF) was recorded in voltage‐clamped bullfrog lumbar sympathetic neurones. At a holding potential of −30 mV, LHRF induced a steady inward (depolarizing) current and reduced membrane conductance; at −60 mV LHRF produced negligible inward current and much less conductance change. The effects of LHRF were accompanied by a reduced amplitude of the slow current relaxations following hyperpolarizing and depolarizing commands, without prominent change in their time‐course. This suggests a selective depression of the voltage‐sensitive outward K+ ‐current which is suppressed by muscarinic agonists.Keywords
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