THE INFLUENCE OF STILBESTROL AND THYROXIN ON GALACTOSE ABSORPTION AND LIVER FUNCTION

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Abstract
Oral and intraven. solns. of galactose were administered on alternate days to 12 dogs and control curves were established. Blood samples were taken at 30, 60 and 90 mins. 4 dogs were given daily intramusc. injs. of 0.5 mg. thyroxin for 22 days. Oral galactose tests were done at 7, 14 and 20 days and were repeated intraven. at 9, 16 and 22 days. 4 dogs received daily intramusc. injs. of 5.0 mg. of stilbestrol and 4 received 10.0 mg. daily for 22 days, following which oral and intraven. galactose tolerance tests were done. 2 dogs from each of these groups were given simultaneous injs. of thyroxin and stilbestrol for 6 succeeding days. The galactose tolerance tests were repeated. Liver biopsies were secured from each dog studied. Thyroxin increased the rate of absorption from the intestinal tract the first 7 days. This was decreased after 14 days and regained in 20 days. Thyroxin produced liver damage with a resulting increase in the blood galactose values as evidenced by the intraven. routes. Stilbestrol increased the rate of absorption of galactose from the intestinal tract and hastened its clearance from the blood. The glyconeogenic function of stilbestrol in this connection was postulated. Stilbestrol plus thyroxin caused an increased rate of absorption and a delay in the clearance of galactose from the blood.

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