Cardiotonic Activity of 9-Alpha Fluorohydrocortisone.

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Abstract
Employing the papillary heart preparation the cardiotonic activity of 9-alpha fluorohydrocortisone was determined. In a concentration of 0.5 - 1.0 [mu]g/ml a positive inotropic action resulted along with an increase intramuscular uptake of Na22 and a loss of K42. Conversely a concentration of 10 - 20 [mu]g/ml resulted in a negative inotropic action along with an intramuscular loss of Na22 and an increased uptake of K42. A histological correlation of these results was shown. Failure was induced in the whole isolated heart preparation by changing the original with fresh perfusate. Addition of 1.0 [mu]g/ml partially overcame this failure. Increasing the concentration to 10.0 [mu]g/ml rapidly brought on failure in the "normal" preparation. Results are presented as evidence of the glycoside-like action of 9-alpha fluorohydrocortisone on isolated cardiac tissue.