A Test of a Linear Model of Glaucomatous Structure–Function Loss Reveals Sources of Variability in Retinal Nerve Fiber and Visual Field Measurements
Open Access
- 1 September 2009
- journal article
- glaucoma
- Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Opthalmology & Visual Science
- Vol. 50 (9) , 4254-4266
- https://doi.org/10.1167/iovs.08-2697
Abstract
Purpose. Retinal nerve fiber (RNFL) thickness and visual field loss data from patients with glaucoma were analyzed in the context of a model, to better understand individual variation in structure versus function. methods. Optical coherence tomography (OCT) RNFL thickness and standard automated perimetry (SAP) visual field loss were measured in the arcuate regions of one eye of 140 patients with glaucoma and 82 normal control subjects. An estimate of within-individual (measurement) error was obtained by repeat measures made on different days within a short period in 34 patients and 22 control subjects. A linear model, previously shown to describe the general characteristics of the structure–function data, was extended to predict the variability in the data. results. For normal control subjects, between-individual error (individual differences) accounted for 87% and 71% of the total variance in OCT and SAP measures, respectively. SAP within-individual error increased and then decreased with increased SAP loss, whereas OCT error remained constant. The linear model with variability (LMV) described much of the variability in the data. However, 12.5% of the patients’ points fell outside the 95% boundary. An examination of these points revealed factors that can contribute to the overall variability in the data. These factors include epiretinal membranes, edema, individual variation in field-to-disc mapping, and the location of blood vessels and degree to which they are included by the RNFL algorithm. conclusions. The model and the partitioning of within- versus between-individual variability helped elucidate the factors contributing to the considerable variability in the structure-versus-function data.Keywords
This publication has 38 references indexed in Scilit:
- Blood Vessel Contributions to Retinal Nerve Fiber Layer Thickness Profiles Measured With Optical Coherence TomographyJournal of Glaucoma, 2008
- An Analysis of Normal Variations in Retinal Nerve Fiber Layer Thickness Profiles Measured With Optical Coherence TomographyJournal of Glaucoma, 2008
- Relationship between Scanning Laser Polarimetry with Enhanced Corneal Compensation and with Variable Corneal CompensationKorean Journal of Ophthalmology, 2008
- Retinal Nerve Fiber Structure versus Visual Field Function in Patients with Ischemic Optic NeuropathyOphthalmology, 2007
- A framework for comparing structural and functional measures of glaucomatous damageProgress in Retinal and Eye Research, 2007
- Structure-Function Relationship Is Stronger with Enhanced Corneal Compensation than with Variable Corneal Compensation in Scanning Laser PolarimetryInvestigative Opthalmology & Visual Science, 2007
- Decreased optical coherence tomography-measured pericentral retinal thickness in patients with diabetes mellitus type 1 with minimal diabetic retinopathyBritish Journal of Ophthalmology, 2007
- Determinants of Normal Retinal Nerve Fiber Layer Thickness Measured by Stratus OCTOphthalmology, 2007
- Visual Field Defects and Retinal Ganglion Cell Losses in Patients With GlaucomaArchives of Ophthalmology (1950), 2006
- Retinal nerve fibre layer thickness measurements in normal Indian population by optical coherence tomographyIndian Journal Of Ophthalmology, 2006