Peripheral vascular responses during acute anemia
- 1 February 1981
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 59 (2) , 102-107
- https://doi.org/10.1139/y81-018
Abstract
Peripheral vascular responses during acute anemia were studied in 19 anesthetized dogs. In one study (n = 9) hindlimb weight and venous pressures were measured prior to and during acute anemia produced by isovolemic dextran-for-blood exchange. In another series of five control and five anemic dogs (hematocrit = 14 ± 1% (mean ± SE)), flow to the limb was occluded and arterial and venous pressure changes in the occluded limb were measured as an index of neurally mediated alterations in limb vasomotor tone. Following reduction of the hematocrit to 14 ± 0.3%, hindlimb weight decreased by an average of 10.0 g (P < 0.01) at 15 min and 12.8 g (P < 0.01) at 30 min of anemia. The decrease in limb weight was associated with a rise (P < 0.01) in limb venous pressure. There was also a relatively greater degree of vasomotor tone in the occluded hindlimb of anemic dogs as compared with control animals. Although both arterial and venous pressures decreased in an occluded hindlimb following the production of anemia, the decreases in vascular pressures were significantly less than those observed in control experiments. It was not possible to distinguish between tone changes in arteries and veins because of the presence of arteriovenous anastomoses. The data show that a peripheral-to-central blood volume translocation occurred in acute anemia which would increase venous return. Further, the results strongly suggest that the volume translocation was a result of an increase in venomotor tone.This publication has 9 references indexed in Scilit:
- Blood flow and oxygen uptake in isolated canine skeletal muscle during acute anemiaJournal of Applied Physiology, 1979
- O2 extraction by hind limb versus whole dog during anemic hypoxiaJournal of Applied Physiology, 1978
- Response of veins of canine limb to aortic and carotid chemoreceptor stimulationAmerican Journal of Physiology-Legacy Content, 1966
- Response of capacity and resistance vessels of dog's limb to sympathetic nerve stimulationAmerican Journal of Physiology-Legacy Content, 1966
- Role of the Autonomic Nervous System in the Circulatory Response to Acutely Induced Anemia in Unanesthetized Dogs *Journal of Clinical Investigation, 1964
- Dextran-exchange anemia and reduction in blood viscosity in the heart-lung preparationAmerican Heart Journal, 1964
- Cardiovascular Effects of Acutely Produced Anemia in the Normal DogAmerican Journal of Physiology-Legacy Content, 1953
- The Influence of Erythrocyte Concentration upon the Pressure-Flow Relationships in the Dog's Hind LimbCirculation Research, 1953
- BLOOD FLOW, PERIPHERAL RESISTANCE AND VASCULAR TONUS, WITH OBSERVATIONS ON THE RELATIONSHIP BETWEEN BLOOD FLOW AND CUTANEOUS TEMPERATUREAmerican Journal of Physiology-Legacy Content, 1944