Variational Approach to Relaxation in Complex Free Energy Landscapes: The Polymer Folding Problem
- 31 March 1997
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 78 (13) , 2668-2671
- https://doi.org/10.1103/physrevlett.78.2668
Abstract
A statistical theory of the folding dynamics of an ensemble of random heteropolymers is developed. The predicted relaxation is consistent with the glassy behavior of quenched disorder and is singled out by a generic least action principle: In processes of increasing difficulty, the logarithmic growth in time of the expected activation barrier yields the fastest relaxation pathway.Keywords
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