Possible Synthesis of Pregnancy-‘Specific’ Beta-1-Glycoprotein (SP1) and Placenta-‘Specific’ Tissue Proteins (PP10, PP12) by Human and Cynomolgus Monkey Leukocytes

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Abstract
Using an enzyme-bridge immunoperoxidase (PAP) technique, it was revealed that pregnancy- and/or placenta-specific proteins, SP1, PP10 and PP12 were localized in human cynomolgus monkey (M. fascicularis) polymorphonuclear neutrophils, and PP10 in mononuclear phagocytes. There was no difference in staining results, irrespective of whether the specimens were from human or monkey males or pregnant or nonpregnant females. SP1, PP10 and PP12 may be synthesized by polymorphonuclear neutrophils and/or mononuclear phagocytes and could represent markers for trophoblasts and some kinds of malignant neoplasms, and also for normal neutrophils and/or monocytes.