Chemical modification of the ester group of diketocoriolin B.
- 1 January 1980
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 33 (4) , 393-403
- https://doi.org/10.7164/antibiotics.33.393
Abstract
5,8-Di-O-tetrahydropyranylcoriolin B (2) was synthesized and its 2 epoxide groups were resistant to alkaline hydrolysis to give di-O-tetrahydropyranyldihydrocoriolin (3). Acylation or alkylation of the free hydroxyl group at C-1 of 3 followed by hydrolysis of the tetrahydropyranylether groups and oxidation of the hydroxyl groups at C-5 and C-8 afforded a number of 1-O-acyl or alkyl analogs of diketocoriolin B. All of them showed antibacterial and antitumor activities.This publication has 1 reference indexed in Scilit:
- Chemical modification of coriolin B.The Journal of Antibiotics, 1977