Enantioselective synthesis of (+)(R)- and (–)(S)-nicotine based on Ir-catalysed allylic amination
- 11 August 2005
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 3 (18) , 3266-3268
- https://doi.org/10.1039/b508634e
Abstract
The synthesis of nicotine with enantiomeric excess of >99% ee was accomplished by asymmetric Ir-catalysed allylic amination followed by ring closing metathesis and racemisation-free double bond reduction.Keywords
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