Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo
- 1 August 1990
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 346 (6285) , 629-633
- https://doi.org/10.1038/346629a0
Abstract
Viruses persist in an immune population, as in the case of influenza, or in an individual, as postulated for human immunodeficiency virus, when they are able to escape existent neutralizing antibody responses by changing their antigens. It is now shown that viruses can in principle escape the immunosurveillance of virus-specific cytotoxic T cells by mutations that alter the relevant T-cell epitope.Keywords
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