Further studies on ether convulsions

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Abstract
Eeg-recorded seizures developed at temperatures ranging from 102 to 106.5[degree]F in 10 dogs subjected to hyperthermia (105 to 107[degree]F) and ether anesthesia. Brain and lung tissue exhibited a high incidence of fat embolism. A good correlation existed between the development of neurologic deficits, microscopic fat emboli, and a decrease in serum phospholipid levels. A 2d group of 10 dogs heparinized before ether anesthesia was made hyperthermic to 110 to 112[degree]F. Of 3 dogs, 2 developed abnormal wave patterns and 1 had eeg evidence of a frank seizure. Only the latter animal developed neurologic deficits and evidence of embolic fat. Neurologic disorders after ether convulsions may be caused by blood sludging from temperature elevation and development of fat emboli, either or both of these factors responding in some fashion to heparinization.

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