Acute Effects of Angiotensin-II-Amide on Aldosterone and Corticosterone Secretion by Morphine-Pentobarbital Treated Rats

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Abstract
Aldosterone and corticosteron were assayed by double isotope derivative dilution in serial samples of adrenal vein blood and in the entire gland after collection, in morphine-pentobarbital treated male rats. Each animal served as its own control, and the secretion rate was compared to the adrenal pool of each steroid to obtain the adrenal turnover rate. Continuous angiotensin infusion (3.6 [mu]g/min) caused significant increases in the secretion of aldosterone, but no significant changes in corticosterone s ecretion. The fractional adrenal turnover rate of the glands showed a decreased turnover for aldosterone and no change for corticosterone. Angiotensin in pharmacological dosage can selectively stimulate aldosterone secretion in the rat.