NEAR FATAL REACTION TO SULFOBROMOPHTHALEIN (BROMSULPHALEIN) LIVER TEST

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Abstract
The determination of sulfobromophthalein (Bromsulphalein) retention is one of the most commonly employed hepatic function studies. Its importance in the diagnosis of liver disease is generally recognized. This procedure has been designated, and is widely regarded, as the most valuable of the excretory tests of liver function.1 While several mild allergic reactions to sulfobromophthalein have been reported, only a few serious effects have been observed.2 The purpose of this paper is to describe a near fatal reaction to this laboratory procedure and to suggest certain precautions in its use. REPORT OF A CASE A 68-year-old Negro man was observed in the antibiotic clinic of the John Gaston Hospital and the University of Tennessee College of Medicine on April 28, 1952. Since Feb. 17, 1949, this patient had been observed by the general medicine clinic because of arteriosclerotic heart disease, with cardiac insufficiency. Medication had consisted of digitalis, ammonium

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