CLINICAL STUDIES OF NEUROPATHY DUE TO MACROGLOBULINEMIA (WALDENSTROMS SYNDROME)

  • 1 January 1963
    • journal article
    • research article
    • Vol. 89  (16) , 806-+
Abstract
A case of severe neuropathy due to macroglobulinemia is reported with clinical, biochemical and electrophysiological studies. The clinical picture was that of a severe, symmetrical polyneuropathy of a sensory-motor type with increased protein in the CSF. Sedimentation rate was increased and a sharp rise was found in the globulin fractions on plasma electrophoresis. Immuno-assays of CSF showed increases of albumin, transferrin and gamma globulin. Blood chromosome studies were normal. EMG showed neuromuscular atrophy. Nerve conduction times were prolonged. These studies are compatible with a neuropathy of an allergic or metabolic nature. Macroglobulinemia of Waldenstrom should be considered in the differential diagnosis of obscure neuro-pathies.