Chemotherapy of Leukemia VII. Effect of Substituted Triazenes on Transplanted Mouse Leukemia.

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Abstract
1-phenyl 3, 3-dimethyl triazene, was shown to prolong survival time of mice with transplanted leukemias 82 and 5471 but not with an Amethopterin sensitive or an Amethopterin resistant variant of leukemia L1210. A closely allied derivative, 1 - p - nitrophenyl - 3,3-dimethyl triazene has shown relatively greater chemotherapeutic activity against leukemia 82 but was inactive against the 2 variants of leukemia L1210. These compounds were also active against strains of leukemia 82 which were either initially refractory to or made resistant to Amethopterin, Azaserine, Amicetin, and Aminonucleoside. Further therapeutic studies on this class of compounds are indicated.