Regulation of Sertoli Cell Function by Thyrotropin

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Abstract
The effects of FSH on Sertoli cells are well documented; however, only recently has TSH been directly implicated in reproductive function. The purpose of this investigation was to test the effects of TSH on androgen binding protein (ABP) and plasminogen activator (PA) secretion by cultured rat Sertoli cells. The results of this investigation demonstrate similar dose-response patterns of ABP secretion with rat FSH and TSH, and human, ovine, and bovine TSH. No effect was observed with rat LH when used in identical doses. Rat TSH and FSH also stimulated PA secretion, but no similar effect was observed with rat LH. These finding further support the hypothesis that TSH has a direct role in male reproductive function, and indicate that Sertoli cells are the primary testicular site of action for this hormone.

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