COMPLEX TRAIT ANALYSIS IN THE MOUSE: The Strengths, The Limitations and The Promise Yet To Come
- 1 December 2000
- journal article
- review article
- Published by Annual Reviews in Annual Review of Genetics
- Vol. 34 (1) , 653-686
- https://doi.org/10.1146/annurev.genet.34.1.653
Abstract
▪ Abstract In 1990, David Baltimore predicted that the 1990s would be the decade of the mouse ( 1 ). This certainly proved to be true: The mouse has contributed immensely to biological research through transgenic, embryonic stem cell (ES) knockout, and classical genetic technologies. But its usefulness as a model organism is by no means over; indeed it is still rising to its peak: The mouse as a model mammalian organism still has much to offer. This article reviews use of the mouse to dissect complex genetic traits using quantitative trait analysis, with a particular emphasis on medically important diseases.Keywords
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