Influence of Animal Tissue Mucopolysaccharides on Transplantable Myelocytic Leukaemia in Rats

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Abstract
Young rats, inoculated with myelocytic chloroleukaemia, were treated with mucopolysaccharide (MPS) concentrates and fractions of animal tissue homogenates. Many groups of treated rats survived significantly longer than the controls. Fractions of bovine liver MPS gave the best results. The most active of these was prepared by absorption of the crude concentrate to Ecteola cellulose, and elution with 2 M NaCl‐HCl solution. However, some failures were noted with similar fractions, probably attributable to the development of varying degrees of resistance. The results were more consistently positive if the treatment was begun 12 days after transplantation than in treatment experiments begun 1–3 days after the inoculation.Aided by grants from the Sigrid Jusélius Foundation, Helsinki, and the Damon Runyon Memorial Fund, New York (DRG, 644, 788).