Fluctuations in the Mitotic Frequency of the Glandular Stomach and Intestine of Rat under the Influence of ACTH, Glucocorticoids, Stress and Heparin

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Abstract
Räsänen, T.Fluctuations in the mitotic frequency of the glandular stomach and intestine of rat under the influence of ACTH, glucocorticoids, stress and heparin.Acta physiol. scand. 1963.58.201–210. — Adrenocorticotrophin in a large single dose, in contrast to the small doses, produced a distinct drop in the mitoses of the gastric mucosa of rat but not in those of the duodenal mucosa. The reducing effect of dexamethasone, prednisolone and cortisol on the mitotic index was biggest for dexamethasone and smallest for cortisol. The change in the mitotic index was smaller in the duodenal epithelium than in the gastric mucosa. Peritonitis produced a slight drop in mitoses in the gastric and duodenal epithelium. An acute stress produced a distinct reduction in mitoses in the gastric but not in the duodenal, jejunal and colonic epithelium. Heparin produced a distinct reduction of mitoses in the gastric epithelium but not in the duodenal epithelium. The reduction in the mitotic frequency is attributed to more rapid cellular changes in the gastric than intestinal lamina propria. A factor reducing mitotic frequency in the gastric mucosa is probably the local, rapid heparinliberation from the mucosal mast cells. The reduction in mitotic frequency following various insults was great in the epithelium of the gastric mucosa, slighter or nonexistent in the intestinal mucosa. This is attributed to more rapid changes in the lamina propria of the gastric mucosa than in the intestinal lamina propria. Another factor reducing mitotic frequency in the gastric mucosa is probably the local, true heparin liberated from the mucosal mast cells.