Cutaneous plasmacytomas in myeloma. Relationship to tumor cell burden

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Abstract
Solitary cutaneous plasmacytomas may occur as benign tumors that are confirmed to the skin, whereas multiple lesions are generally associated with systemic plasma cell disease. Cutaneous plasmacytomas developed in 2 patients with documented multiple myeloma. This development occurred late in the course of their disease at a time when their systemic plasma cell tumor burden was large-approximately 3 kg in mass, which represented 2-3 .times. 1012 cells. The occurrence of cutaneous plasmacytomas in patients with multiple myeloma is generally late in the course of the disease and should be considered as a bad prognostic sign.