Differential Effects of Sodium Meglumine Calcium Metrizoate on the Inotropic State of Normal and Ischemic Myocardium

Publisher Website
Google Scholar
Abstract
Sodium meglumine calcium metrizoate was injected into isolated blood-perfused canine hearts to evaluate the effect of contrast agents containing Ca on normal and ischemic myocardium. Under normal perfusion pressure and mild ischemia, this contrast agent produced a positive inotropic effect, but during profound ischemia, this positive effect was followed by a period of myocardial depression. The addition of an inotropic agent to contrast medium apparently can produce a paradoxical depressant effect which can be deleterious to the ischemic myocardium.