Biosynthesis of streptothricin antibiotics. I. Incorporation of 14C-labeled compound into racemomycin-A and distribution of radioactivity.

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Abstract
As a part of the investigation on the biosynthesis of streptothricin antibiotics, the incorporation of 14C-labeled D-glucose, L-lysine, L-arginine, acetic acid and sodium bicarbonate into racemomycin-A from Streptomyces lavendulae ISP 5069 was examined. By the analysis of the degradation products from 14C-labeled racemomycin-A produced by the addition of lysine, a high rate of the isotope was present in the .beta.-lysine moiety. Incorporation of glucose followed by degradation of racemomycin-A demonstrated that glucose was incorporated into gulosamine moiety. Acetic acid was incorporated into streptolidine moiety and carbonate showed a preferential incorporation into a carbamoyl group.

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