The Molecular Basis of MHC-Restricted Antigen Recognition by T Cells
- 1 January 1988
- journal article
- review article
- Published by Taylor & Francis in International Reviews of Immunology
- Vol. 3 (3) , 147-174
- https://doi.org/10.3109/08830188809051187
Abstract
In order to determine the contribution of the clonotypic T cell receptor (Ti) alpha beta heterodimer to the antigen/MHC specificity of mature T cells, we have transfected cloned Ti alpha and/or beta genes into either human or mouse T cells, and analyzed the transfectants for Ti-T3 expression and responses to antigen and Ia molecules. Our analysis establishes that a single receptor structure (the Ti alpha beta heterodimer) is necessary and sufficient to define the dual specificity of T cell antigen recognition and suggests that in at least certain instances Ti beta chains play a predominant role in MHC restriction specificity, raising the possibility of a "one receptor, two sites" model of T cell recognition.Keywords
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